Coronavirus deaths have surged past 150,000 worldwide with nearly a quarter of them in the United States, where President Donald Trump lent his support to protestors rallying against lockdown orders.
Evidence is mounting that social distancing successfully slowed the pandemic after more than half of humanity -- 4.5 billion people -- were confined to their homes.
Governments around the world are now grappling with when and how to ease lockdowns that have crippled the global economy, even as the COVID-19 death toll climbs further in hard-hit countries.
Demonstrators in three US states assembled in public this week to call for an end to the restrictions, with the largest protest in Michigan attracting 3,000 people -- some of whom were armed.
Trump has largely left decisions on easing lockdowns to state officials even as he outlined guidelines for a staged reopening of the national economy.
The US accounts for nearly a third of the 2.2 million coronavirus infections reported globally.
It has also recorded around 37,000 deaths, more than any other nation, followed by Italy, Spain and France which have all been ravaged by their own outbreaks.
However, these figures likely reflect only a fraction of the actual number of infections, because many countries are testing only the most serious cases.
Virtually no corner of the world has been left untouched, with deaths in Africa passing 1,000 overnight.
Nigeria announced the death of President Muhammadu Buhari's top aide on Saturday, the highest-profile person to succumb to the virus in Africa's most populous nation.
China sharply raised its own death toll to 4,636 on Friday after adding another 1,290 fatalities for the city of Wuhan, where the respiratory disease first emerged late last year.
Trump, who has angrily shot back at claims he reacted too slowly to the virus threat, has accused Beijing of downplaying the impact of the virus within its borders.
Leaders in France and Britain have also questioned China's management of the crisis but Beijing hit back, saying it had not concealed information about the illness.
Signs that the outbreak could be easing in parts of Europe prompted Switzerland, Denmark and Finland to begin reopening shops schools this week.
Germany's health minister said infection rates had "sunk significantly" after 3,400 deaths in his country, which is now beginning the delicate task of lifting some restrictions without triggering a secondary outbreak.
Some small shops will be allowed to reopen Monday, and some children would return to school within weeks.
Parts of Italy also began emerging from lockdown, with Venice residents strolling around quiet canals.
But Japan, Britain and Mexico all expanded their current movement
Signs of the economic damage of the pandemic are mounting, with China reporting its first contraction in GDP in several decades.
African state leaders and global financial bodies warned on Friday that the continent needed tens of billions of dollars in additional funds to fight the outbreak.
The IMF also warned the virus could spark another "lost decade" in Latin America and backed debt moratoriums to free up spending for the region's fragile economies. (AFP)