COVID-19: Antibody therapy may lower hospitalizations, emergency visits, study finds

Tidio Live Chat Software - Add Tidio live chat software to your website in minutes. Contact visitors and turn them into happy customers. Enhance their experience and boost your sales. Get it for Free

WP Rocket - WordPress Caching Plugin

Must Read

COVID-19 patients who were administered a novel antibody had fewer symptoms and were less likely to require hospitalization or emergency medical care than those who did not receive the therapy, according to a new study.

The ongoing Phase II clinical trial, whose interim results were published in The New England Journal of Medicine, tested three different doses of LY-CoV555, a monoclonal antibody derived from the blood of a recovered COVID-19 patient.

Also Read

The analysis indicated a reduced viral load in outpatients with mild to moderate cases of COVID-19 at the 2,800-milligram dosage level, along with reduced rates of hospitalisation and emergency medical care among patients at all dosage levels.

“For me, the most significant finding was the reduction in hospitalisations,” said the study’s co-first author, Peter Chen from the Cedars-Sinai Medical Center in the US.

Elegant Themes - The most popular WordPress theme in the world and the ultimate WordPress Page Builder. Get a 30-day money-back guarantee. Get it for Free

“Monoclonal antibodies like this have the potential to reduce the severity of COVID-19 for many patients, allowing more people to recover at home,” Chen said.

According to the researchers, monoclonal antibodies work by attaching themselves to a virus and preventing it from replicating.

They said LY-CoV555 binds to a particular protein on the novel coronavirus, called the spike protein, which the virus needs to enter human cells and replicate.

By preventing the virus from replicating, the scientists said the antibody slows down the replication process, allowing the patient’s own immune system time to kick into gear.

“What we’re doing is preventing the virus from causing too much damage early on in the process,” Chen said.

“We’re buying the patients time, so that their bodies can start developing their own immunity to fight the virus,” he added.

In the study, the patients were given intravenous doses of either 700, 2,800 or 7,000 milligrams of the antibody, or a placebo.

“In this interim analysis of a phase 2 trial, one of three doses of neutralising antibody LY-CoV555 appeared to accelerate the natural decline in viral load over time, whereas the other doses had not by day 11,” the scientists wrote in the study.

The researchers used a nasopharyngeal swab to test patients’ viral load before administering the antibody and again at several points after administering the drug.

They also gave the patients a questionnaire about their subsequent symptoms and treatment.

According to the study, nearly 300 patients received the treatment (100 patients per dosage level), and approximately 150 patients received the placebo.

Of the three dosage levels, the scientists said the 2,800-milligram dosage was shown to be effective in reducing viral load.

By day 11, they said the viral load was substantially diminished for most patients, including those in the placebo arm.

However the researchers said further studies will be needed to validate these results.

“The publication of these data in a peer-reviewed journal adds to the growing body of evidence for the potential utility for neutralising antibodies as therapeutics for people recently diagnosed with mild to moderate COVID-19, particularly high-risk patients,” said Ajay Nirula, another co-author of the study.

“These data show LY-CoV555 may be effective in treating COVID-19 by reducing viral load, symptoms, and the risk of hospitalization in outpatients,” Nirula said.

At day 29, the study noted that hospitalisation rates were only 1.6 per cent in the antibody-treated group, compared with 6.3 per cent in the group that received the placebo.

The researchers said the reduction in hospitalisations was seen across all demographic groups, including those in high-risk categories — adults older than 65 and those with a high body mass index (greater than 35).

For high-risk patients, they said the hospitalisation rates were 4.2 per cent in patients treated with the antibody, compared with 14.6 per cent in placebo-treated patients.

The safety profile of patients treated with LY-CoV555 was similar to that of placebo-treated patients, the study noted.

“We know that COVID-19 is especially hard on the elderly, the obese and people with certain pre-existing health conditions,” Chen said.

“Antibody treatments like this may have the most benefits for people in these higher-risk categories,” he added.

iThemes WordPress Hosting

Stay updated

Subscribe to our newsletter and never miss an update on the latest tech, gaming, startup, how to guide, deals and more.



- Advertisement -
- Advertisement -


Grow Your Business

Place your brand in front of tech-savvy audience. Partner with us to build brand awareness, increase website traffic, generate qualified leads, and grow your business.

- Advertisement -

Grow Your Business

Get these business solutions, tools and services to help your business grow.

Elementor -Join 5,000,000+ Professionals Who Build Better Sites With Elementor. Build your website with 100% visual design that loads faster and speeds up the process of building them.

WP Rocket

WP Rocket - Speed up your website with the most powerful caching plugin in the world. The website speed increase means better SEO ranking, user experience, and conversation. It’s a fact that Google loves a fast site.


Kinsta - If you are looking for WordPress managed hosting, Kinsta is in the leading front. Kinsta provides WordPress hosting for a small or large business that helps take care of all your needs regarding your website with cutting-edge technology.


OptinMonster - Instantly boost leads and grow revenue with the #1 most powerful conversion optimization toolkit in the world. 700,000+ websites are using OptinMonster to turn their traffic into leads, subscribers, and sales.


- Advertisement -
- Advertisement -
India to Produce Upcoming iPhones: Trade Minister Japanese Professor Developed A Power Semiconductor made of Diamond Google Releases New Product for India’s Merchants Indian EV Startup Unveil Two AutoBalancing Electric Scooters OPPO Find X6 Pro Images Render via Weibo Sony Develops New Tech to Reduce Noise of Image Sensors Tesla’s S & Y Models Earn Best-in-Class Cars of 2022 India Approved $320m to Promote Homegrown Payments Network Twitter Roll Out TikTok-like ‘For You’ Timeline on iOS Nothing Phone Enters US with Beta Membership Program
Finally! Apple’s VR Headset Coming this Spring Harvard Scientists Develop New Cell Therapy to Kill, and Prevent Brain Cancer HTC Vive XR Elite VR/AR Headset Now Selling for $1099 Realme 10 Launched in India with Helio G99 Gaming Chipset Twitter Data Breach Revealing User’s Private Information Instagram New Feature to Create Albums With Friend Redmi Note12 Pro Plus Launched in India POCO C50 Launched in India