AstraZeneca’s Nasal Vaccination Prevents Covid Spread in Animal Models

Tidio Live Chat Software - Add Tidio live chat software to your website in minutes. Contact visitors and turn them into happy customers. Enhance their experience and boost your sales. Get it for Free

WP Rocket - WordPress Caching Plugin

Must Read

AstraZeneca’s intranasal Covid vaccination reduced virus concentrations and curbed transmission in two different SARS-CoV-2 animal models, demonstrating the need for further investigation as a potential method of inoculating Covid-19 shots.

The trial, led by researchers from the US National Institutes of Health (NIH) and the University of Oxford, UK, was published in the journal Science Translational Medicine.

Also Read

While previous studies in rhesus macaques revealed that intramuscular vaccination with AstraZeneca Covid shot provided protection against pneumonia, it did not reduce the shedding of SARS-CoV-2 from the upper respiratory tract.

In the new study, intranasal vaccination of rhesus macaques and hamsters resulted in reduced virus concentrations in nasal swabs and a reduction in viral loads in bronchoalveolar lavage and lower respiratory tract tissue.

Elegant Themes - The most popular WordPress theme in the world and the ultimate WordPress Page Builder. Get a 30-day money-back guarantee. Get it for Free

“The data presented supports the investigation of intranasal delivery of Covid-19 vaccines. With the roll-out of Covid-19 vaccines worldwide, it will be crucial to investigate whether the vaccines provide sterilizing immunity, or whether vaccinated people are still susceptible to infection of the upper respiratory tract and onward transmission of the virus,” Vincent J Munster, from the Laboratory of Virology at the NIH’s National Institute of Allergy and Infectious Diseases.

The data presented here demonstrate SARS-CoV-2-specific mucosal immunity is possible after intranasal vaccination and results in a reduction in virus detection in nasal swabs in hamsters and macaques, he added.

The team investigated whether intranasally administered ChAdOx1 nCoV-19 (AstraZeneca’s intranasal Covid vaccine) reduces detection of virus in nasal swabs after challenging vaccinated macaques and hamsters with SARS-CoV-2 carrying a D614G mutation (the original Covid variant) in the spike protein.

“Viral loads in swabs obtained from intranasally vaccinated hamsters were decreased compared to control hamsters, and no viral RNA or infectious virus was found in lung tissue after a direct challenge or after direct contact with infected hamsters,” Munster said.

The macaques “exhibited low titers of IgG and IgA antibodies in nasosorption samples coupled with low virus-neutralizing (VN) and sera IgG titers, suggesting that a robust humoral response in the nasal mucosa and in circulation is necessary to efficiently control nasal shedding,” he added.

Although protection of the lower respiratory tract was complete in intranasal-vaccinated animals, only partial control was seen in intramuscular-vaccinated animals, in contrast to the direct challenge experiment, the researchers said.

The team also mentioned that the animal numbers were limited and although differences were observed and were very encouraging between intranasally vaccinated and control animals, these were not significant.

The University of Oxford has started a phase 1 clinical trial including 54 healthy adults to investigate intranasal vaccination of human volunteers.

iThemes WordPress Hosting

Stay updated

Subscribe to our newsletter and never miss an update on the latest tech, gaming, startup, how to guide, deals and more.



- Advertisement -
- Advertisement -


Grow Your Business

Place your brand in front of tech-savvy audience. Partner with us to build brand awareness, increase website traffic, generate qualified leads, and grow your business.

- Advertisement -

Grow Your Business

Get these business solutions, tools and services to help your business grow.

Elementor -Join 5,000,000+ Professionals Who Build Better Sites With Elementor. Build your website with 100% visual design that loads faster and speeds up the process of building them.

WP Rocket

WP Rocket - Speed up your website with the most powerful caching plugin in the world. The website speed increase means better SEO ranking, user experience, and conversation. It’s a fact that Google loves a fast site.


Kinsta - If you are looking for WordPress managed hosting, Kinsta is in the leading front. Kinsta provides WordPress hosting for a small or large business that helps take care of all your needs regarding your website with cutting-edge technology.


OptinMonster - Instantly boost leads and grow revenue with the #1 most powerful conversion optimization toolkit in the world. 700,000+ websites are using OptinMonster to turn their traffic into leads, subscribers, and sales.


- Advertisement -
- Advertisement -
ChatGPT Reaches 100 Million Users in Two Months Microsoft’s Teams Get OpenAI-Based Features WhatsApp New Feature that Allows Users to Create Calling Shortcuts Instagram Working On Twitter-like Paid Verification Feature OnePlus Ace 2 Specs Exposed Online Realme GT Neo 5 Full Specs Revealed  Samsung Galaxy S23 Ultra: The New Android King Twitter To End Free API February 9 MLS Season Pass Now Available On Apple TV App Tesla To Increase Giga Shanghai EV Production to 20,000 Weekly 
OpenAI Releases Tool To Detect AI-generated Text Tesla Records Double Net Profit in 2022 India to Produce Upcoming iPhones: Trade Minister Japanese Professor Developed A Power Semiconductor made of Diamond Google Releases New Product for India’s Merchants Indian EV Startup Unveil Two AutoBalancing Electric Scooters OPPO Find X6 Pro Images Render via Weibo Sony Develops New Tech to Reduce Noise of Image Sensors